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Newly Published Review of Environmental and
Human Health Effects of Octylphenol
July 6, 2005
A recently published manuscript in the journal Human and Ecological Risk Assessment1 reviewed the weight of evidence of aquatic and mammalian toxicology data on para-tert-octylphenol (OP; CAS RN 140-66-9). OP is an important chemical intermediate mainly used for production of phenolic resins and lacquers. OP has weak estrogen-like activity with a much lower potency than predicted by in vitro activity. This article reviews the results of the definitive toxicological assays in mammalian and aquatic species to those of the in vitro screening tests. The findings show that the estrogen-like activity in screening tests is not predictive of results from definitive testing and that risk assessment decisions should be made using conventional toxicity endpoints.
To obtain reprints of the manuscript please contact APERC at info@aperc.org.
1 Van Miller, J.P., and Staples, C.A. (2005). Review of the potential environmental and human health-related hazards and risks from long-term exposure to p-tert-octylphenol. Human and Ecological Risk Assessment, 11, 319-351.
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